The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View.

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作者： Luca,Unione ^[1] ; María J,Moure ^[1] ; Maria Pia,Lenza ^[1] ; Iker,Oyenarte ^[1] ; June,Ereño-Orbea ^[2] ; Ana,Ardá ^[2] ; Jesús,Jiménez-Barbero ^[3]

作者单位： CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48162 Derio, Bizkaia, Spain. ^[1] CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48162 Derio, Bizkaia, Spain.;Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Bizkaia, Spain. ^[2] CICbioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48162 Derio, Bizkaia, Spain.;Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Bizkaia, Spain.;Department of Organic Chemistry, II Faculty of Science and Technology University of the Basque Country, EHU-UPV, 48940, Leioa, Spain.;Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), 28029, Madrid, Spain. ^[3]

关键词 13C-Labelling Molecular Recognition NMR Spectroscopy SARS-Cov2 Sialic Acid

主题词结合部位(Binding Sites);半乳糖(Galactose);人类(Humans);N-乙酰神经氨酸(N-Acetylneuraminic Acid);唾液酸类(Sialic Acids);三糖类(Trisaccharides)

DOI 10.1002/anie.202201432

PMID 35191576

发布时间 2024-08-27

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