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Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner.

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第一作者： Ibo,Janssens

第一单位： Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: ibo.janssens@uantwerpen.be.

作者： Ibo,Janssens ^[1] ; Diana,Campillo Davó ^[2] ; Jasper,Van den Bos ^[2] ; Hans,De Reu ^[2] ; Zwi N,Berneman ^[3] ; Inez,Wens ^[2] ; Nathalie,Cools ^[3]

作者单位： Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: ibo.janssens@uantwerpen.be. ^[1] Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. ^[2] Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium. ^[3]

关键词 T cell receptor adoptive cell therapy antigen specificity good manufacturing practice mRNA-electroporation regulatory T cells

医学主题词电穿孔(Electroporation);叉头转录因子类(Forkhead Transcription Factors);RNA, 信使(RNA, Messenger);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)

DOI 10.1016/j.jcyt.2022.01.001

PMID 35193826

发布时间 2022-06-29

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