Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis.

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作者： Ng,Desi ^[1] ; Qing Yun,Tong ^[2] ; Velda,Teh ^[1] ; Jia Jia,Chan ^[1] ; Bin,Zhang ^[1] ; Hossein,Tabatabaeian ^[1] ; Hui Qing,Tan ^[1] ; Katannya,Kapeli ^[3] ; Wenhao,Jin ^[3] ; Chun You,Lim ^[3] ; Zhi Hao,Kwok ^[1] ; Hwee Tong,Tan ^[1] ; Shi,Wang ^[4] ; Bei-En,Siew ^[2] ; Kuok-Chung,Lee ^[5] ; Choon-Seng,Chong ^[6] ; Ker-Kan,Tan ^[7] ; Henry,Yang ^[6] ; Dennis,Kappei ^[7] ; Gene W,Yeo ^[6] ; Maxey Ching Ming,Chung ^[7] ; Yvonne,Tay ^[1]

作者单位： Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. ^[1] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore. ^[2] Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. ^[3] Division of Pulmonary and Critical Care, Boston University, Boston, MA, 02118, USA. ^[4] Department of Pathology, National University Health System, Singapore, Singapore. ^[5] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ^[6] Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore. ^[7] Department of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California, La Jolla, San Diego, USA. ^[8] Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. yvonnetay@nus.edu.sg. ^[9] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore. yvonnetay@nus.edu.sg. ^[10]

关键词 Cancer LARP1 MYC Post-transcriptional regulation RNA-binding protein