首页> Cell reports> Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors.

Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors.

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第一作者： Nishanth Belugali,Nataraj

第一单位： Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

作者： Nishanth Belugali,Nataraj ^[1] ; Ashish,Noronha ^[1] ; Joo Sang,Lee ^[2] ; Soma,Ghosh ^[1] ; Harsha Raj,Mohan Raju ^[3] ; Arunachalam,Sekar ^[1] ; Binyamin,Zuckerman ^[1] ; Moshit,Lindzen ^[1] ; Emilio,Tarcitano ^[1] ; Swati,Srivastava ^[1] ; Michael,Selitrennik ^[4] ; Ido,Livneh ^[5] ; Diana,Drago-Garcia ^[1] ; Oscar,Rueda ^[6] ; Carlos,Caldas ^[6] ; Sima,Lev ^[3] ; Tamar,Geiger ^[7] ; Aaron,Ciechanover ^[5] ; Igor,Ulitsky ^[1] ; Rony,Seger ^[1] ; Eytan,Ruppin ^[2] ; Yosef,Yarden ^[8]

作者单位： Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. ^[1] Cancer Data Science Lab, National Cancer Institute, NIH, Rockville, MD, USA. ^[2] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ^[3] Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ^[4] Technion Integrated Cancer Center (TICC) and the Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel. ^[5] Cancer Research UK Cambridge Institute, University of Cambridge and the Cambridge Cancer Centre, Department of Oncology, Cambridge, UK. ^[6] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ^[7] Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel. Electronic address: yosef.yarden@weizmann.ac.il. ^[8]

关键词 EGF/ERK TGF-β/SMAD WNT/β-catenin breast cancer cancer hallmark importin metastasis nuclear pore nuclear transport transcription factor