Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys.

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作者： Marc,Morissette ^[1] ; Mélanie,Bourque ^[1] ; Marie-Ève,Tremblay ^[2] ; Thérèse,Di Paolo ^[3]

作者单位： Centre de Recherche du CHU de Québec, Axe Neurosciences, 2705, Boulevard Laurier, Quebec, QC G1V 4G2, Canada. ^[1] Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C2, Canada. ^[2] Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC V6I 1Z3, Canada. ^[3] Faculté de Pharmacie, Université Laval, Pavillon Ferdinand-Vandry, 1050, Avenue de la Médecine, Quebec, QC G1V 0A6, Canada. ^[4]

关键词 CD68 GFAP Iba1 L-Dopa L-Dopa-induced dyskinesias MPEP MPTP monkey Parkinson basal ganglia inflammation

主题词 1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine);动物(Animals);脑(Brain);运动障碍, 药物性(Dyskinesia, Drug-Induced);人类(Humans);炎症(Inflammation);左旋多巴(Levodopa);成束猴(Macaca fascicularis);帕金森病(Parkinson Disease);吡啶类(Pyridines)

DOI 10.3390/cells11040691

PMID 35203338

发布时间 2022-04-08

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2022年11卷4期

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Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys.

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Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys.

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