The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis.

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作者： Ettore,Dolcetti ^[1] ; Antonio,Bruno ^[1] ; Federica,Azzolini ^[1] ; Luana,Gilio ^[1] ; Alessandro,Moscatelli ^[2] ; Francesca,De Vito ^[3] ; Luigi,Pavone ^[1] ; Ennio,Iezzi ^[1] ; Stefano,Gambardella ^[1] ; Emiliano,Giardina ^[1] ; Rosangela,Ferese ^[4] ; Fabio,Buttari ^[5] ; Francesca Romana,Rizzo ^[6] ; Roberto,Furlan ^[1] ; Annamaria,Finardi ^[1] ; Alessandra,Musella ^[1] ; Georgia,Mandolesi ^[7] ; Livia,Guadalupi ^[7] ; Diego,Centonze ^[8] ; Mario,Stampanoni Bassi ^[9]

作者单位： Neurology Unit, IRCSS Neuromed, 86077 Pozzilli, Italy. ^[1] Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy. ^[2] Laboratory of Neuromotor Physiology, IRCSS Fondazione Santa Lucia, 00179 Rome, Italy. ^[3] Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy. ^[4] Genomic Medicine Laboratory, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy. ^[5] Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy. ^[6] Clinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy. ^[7] Synaptic Immunopathology Lab, IRCCS San Raffaele Roma, 00163 Rome, Italy. ^[8] Department of Human Sciences and Quality of Life Promotion, University of Rome San Raffaele, 00163 Rome, Italy. ^[9]

关键词 BDNF Val66Met cytokines inflammation multiple sclerosis neurodegeneration rs6265

主题词脑源性神经营养因子(Brain-Derived Neurotrophic Factor);人类(Humans);炎症(Inflammation);磁共振成像(Magnetic Resonance Imaging);多发性硬化(Multiple Sclerosis);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.3390/genes13020332

PMID 35205376

发布时间 2022-05-31

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