Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis.

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作者： Nathaniel R,Braffman ^[1] ; Terry B,Ruskoski ^[2] ; Katherine M,Davis ^[3] ; Nathaniel R,Glasser ^[1] ; Cassidy,Johnson ^[1] ; C Denise,Okafor ^[2] ; Amie K,Boal ^[3] ; Emily P,Balskus ^[2]

作者单位： Department of Chemistry and Chemical Biology, Harvard University, Cambridge, United States. ^[1] Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, United States. ^[2] Department of Chemistry, The Pennsylvania State University, University Park, United States. ^[3] Howard Hughes Medical Institute, Harvard University, Cambridge, United States. ^[4]

关键词 E. coli X-ray crystallography alkyl halide aromatic alkylation biochemistry chemical biology cyanobacteria cylindrospermum licheniforme molecular biophysics natural product biosynthesis structural biology

主题词烷化作用(Alkylation);碳(Carbon);催化作用(Catalysis);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);氰基细菌(Cyanobacteria)

DOI 10.7554/eLife.75761

PMID 35212625

发布时间 2022-04-29

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