Hsp70 promotes maturation of uromodulin mutants that cause familial juvenile hyperuricemic nephropathy and suppresses cellular damage.

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作者： Sulistiyati Bayu,Utami ^[1] ; Ryo,Endo ^[2] ; Toshihiro,Hamada ^[3] ; Tomomi,Notsu ^[4] ; Hiroyuki,Minato ^[1] ; Koji,Komatsu ^[3] ; Yuji,Nakayama ^[5] ; Yasuaki,Shirayoshi ^[6] ; Kazuhiro,Yamamoto ^[1] ; Shinichi,Okada ^[7] ; Haruaki,Ninomiya ^[8] ; Akihiro,Otuki ^[9] ; Ichiro,Hisatome ^[3]

作者单位： Department of Genetic Medicine and Regenerative Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan. ^[1] Department of Cardiology and Vascular Medicine, Diponegoro University, Semarang, Indonesia. ^[2] Department of Anesthesiology, Faculty of Medicine, Tottori University, Yonago, Japan. ^[3] Department of Community-Based Family Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. thamada@tottori-u.ac.jp. ^[4] Department of Psychiatry, Faculty of Medicine, Tottori University, Yonago, Japan. ^[5] Research Center for Bioscience and Technology, Tottori University, Yonago, Japan. ^[6] Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. ^[7] Department of Pediatrics, Yonago Medical Center, Yonago, Japan. ^[8] Department of Biological Regulation, Faculty of Medicine, Tottori University, Yonago, Japan. ^[9] Department of Cardiovascular Medicine, Yonago Medical Center, Yonago, Japan. ^[10]

关键词 Apoptosis FJHN GGA Hsp70 Uromodulin