The efficient development of a novel recombinant adenovirus zoster vaccine perfusion production process.

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作者： Jianqi,Nie ^[1] ; Yang,Sun ^[2] ; Kai,Feng ^[2] ; Lingling,Huang ^[2] ; Ye,Li ^[3] ; Zhonghu,Bai ^[4]

作者单位： The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. ^[1] Institute of Microbial Engineering, School of Life Sciences, Henan University, Kaifeng 475004, China; Engineering Research Center for Applied Microbiology of Henan Province, Kaifeng 475004, China. ^[2] National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China. Electronic address: yeli0622@jiangnan.edu.cn. ^[3] National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi 214122, China; The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, China. Electronic address: baizhonghu@jiangnan.edu.cn. ^[4]

关键词 Adenovirus HEK 293 cells Perfusion cultivation Process optimization Zoster vaccine

主题词腺病毒科(Adenoviridae);生物反应器(Bioreactors);HEK293细胞(HEK293 Cells);带状疱疹疫苗(Herpes Zoster Vaccine);人类(Humans);灌流(Perfusion);病毒培养(Virus Cultivation)

DOI 10.1016/j.vaccine.2022.02.024

PMID 35216843

发布时间 2022-12-21

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