Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury.

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作者： Dongxuan,Huang ^[1] ; Pengfei,Chen ^[1] ; Guoqing,Huang ^[1] ; Huimin,Sun ^[1] ; Xiaohua,Luo ^[1] ; Chaowen,He ^[1] ; Fei,Chen ^[1] ; Yong,Wang ^[1] ; Changchun,Zeng ^[1] ; Lianhui,Su ^[1] ; Xiaobin,Zeng ^[2] ; Jiachun,Lu ^[2] ; Shiyue,Li ^[2] ; Dongsheng,Huang ^[3] ; Hanchao,Gao ^[4] ; Mengtao,Cao ^[5]

作者单位： Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, 518110, China. ^[1] The State Key Lab of Respiratory Disease, The First Affiliated Hospital, The Institute for Chemical Carcinogenesis, School of Public Health, Guangzhou Medical University, Guangzhou, 510182, China. ^[2] Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, 518110, China. dr_hds@163.com. ^[3] Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, 518110, China. hcgao@foxmail.com. ^[4] Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Affiliated Central Hospital of Shenzhen Longhua District, Guangdong Medical University, Shenzhen, 518110, China. cmtbnu@163.com. ^[5]

主题词动物(Animals);细胞凋亡(Apoptosis);小鼠(Mice);苯脲化合物(Phenylurea Compounds);嘧啶类(Pyrimidines);受体作用蛋白丝氨酸苏氨酸激酶类(Receptor-Interacting Protein Serine-Threonine Kinases)

DOI 10.1038/s41419-022-04633-y

PMID 35217652

发布时间 2022-10-24

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准确一般字义偏差语意偏离译文作用小提交