Design, synthesis and antibacterial evaluation of pleuromutilin derivatives.

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作者： Guangxu,Wu ^[1] ; Zihao,Zhu ^[2] ; Jishun,Li ^[2] ; Xinyu,Luo ^[2] ; Wenyong,Zhu ^[3] ; Guoyang,Liao ^[3] ; Jie,Xia ^[2] ; Wenxuan,Zhang ^[2] ; Weidong,Pan ^[4] ; Tianlei,Li ^[5] ; Song,Wu ^[6]

作者单位： State Key Laboratory of Functions and Applications of Medicinal Plants/School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. ^[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. ^[2] Institute of Medical Biology, Peking Union Medical College and Chinese Academy of Medical Sciences, Kunming 650031, Chin. ^[3] State Key Laboratory of Functions and Applications of Medicinal Plants/School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China. ^[4] State Key Laboratory of Functions and Applications of Medicinal Plants/School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: litianlei818@163.com. ^[5] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address: ws@imm.ac.cn. ^[6]

关键词 Antibacterial agents Design and synthesis Gram-positive pathogens New pleuromutilin derivatives Structure-activity relationship Urea/thiourea functionalities

主题词抗菌药(Anti-Bacterial Agents);二萜类(Diterpenes);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);微生物敏感性试验(Microbial Sensitivity Tests);多环化合物(Polycyclic Compounds);金黄色葡萄球菌(Staphylococcus aureus);尿素(Urea)

DOI 10.1016/j.bmc.2022.116676

PMID 35220163

发布时间 2023-12-13

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