换一批
换一批Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
作者：
Nadilly,Bonagas [1]
;
Nina M S,Gustafsson [1]
;
Martin,Henriksson [1]
;
Petra,Marttila [1]
;
Robert,Gustafsson [2]
;
Elisée,Wiita [1]
;
Sanjay,Borhade [1]
;
Alanna C,Green [3]
;
Karl S A,Vallin [1]
;
Antonio,Sarno [4]
;
Richard,Svensson [5]
;
Camilla,Göktürk [1]
;
Therese,Pham [1]
;
Ann-Sofie,Jemth [1]
;
Olga,Loseva [1]
;
Victoria,Cookson [3]
;
Nicole,Kiweler [6]
;
Lars,Sandberg [7]
;
Azita,Rasti [1]
;
Judith E,Unterlass [1]
;
Martin,Haraldsson [8]
;
Yasmin,Andersson [9]
;
Emma R,Scaletti [10]
;
Christoffer,Bengtsson [7]
;
Cynthia B J,Paulin [1]
;
Kumar,Sanjiv [1]
;
Eldar,Abdurakhmanov [11]
;
Linda,Pudelko [1]
;
Ben,Kunz [1]
;
Matthieu,Desroses [1]
;
Petar,Iliev [1]
;
Katarina,Färnegårdh [7]
;
Andreas,Krämer [12]
;
Neeraj,Garg [13]
;
Maurice,Michel [1]
;
Sara,Häggblad [14]
;
Malin,Jarvius [15]
;
Christina,Kalderén [1]
;
Amanda Bögedahl,Jensen [1]
;
Ingrid,Almlöf [1]
;
Stella,Karsten [1]
;
Si Min,Zhang [1]
;
Maria,Häggblad [14]
;
Anders,Eriksson [16]
;
Jianping,Liu [16]
;
Björn,Glinghammar [8]
;
Natalia,Nekhotiaeva [16]
;
Fredrik,Klingegård [7]
;
Tobias,Koolmeister [1]
;
Ulf,Martens [14]
;
Sabin,Llona-Minguez [1]
;
Ruth,Moulson [1]
;
Helena,Nordström [11]
;
Vendela,Parrow [15]
;
Leif,Dahllund [9]
;
Birger,Sjöberg [8]
;
Irene L,Vargas [1]
;
Duy Duc,Vo [13]
;
Johan,Wannberg [13]
;
Stefan,Knapp [12]
;
Hans E,Krokan [4]
;
Per I,Arvidsson [8]
;
Martin,Scobie [1]
;
Johannes,Meiser [6]
;
Pål,Stenmark [10]
;
Ulrika Warpman,Berglund [1]
;
Evert J,Homan [1]
;
Thomas,Helleday [17]
作者单位：
Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
[1]
Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.
[2]
Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK.
[3]
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
[4]
Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala University, Uppsala, Sweden.
[5]
Cancer Metabolism Group, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.
[6]
Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden.
[7]
Drug Discovery and Development Platform, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, Sweden.
[8]
Drug Discovery and Development Platform, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, Solna, Sweden.
[9]
Department of Biochemistry & Biophysics, Stockholm University, Stockholm, Sweden.;Department of Experimental Medical Science, Lund University, Lund, Sweden.
[10]
Drug Discovery and Development Platform, Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden.
[11]
Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
[12]
Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
[13]
Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.
[14]
Department of Medical Sciences, Division of Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.
[15]
Karolinska High Throughput Centre, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
[16]
Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden. thomas.helleday@scilifelab.se.;Weston Park Cancer Centre, Department of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK. thomas.helleday@scilifelab.se.
[17]
主题词
氨基水解酶类(Aminohydrolases);人类(Humans);水解酶类(Hydrolases);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);亚甲基四氢叶酸脱氢酶(NADP)(Methylenetetrahydrofolate Dehydrogenase (NADP));胸苷(Thymidine)
DOI
10.1038/s43018-022-00331-y
PMID
35228749
发布时间
2024-08-24
- 浏览2
Nature cancer
Nature cancer
2022年3卷2期
156-172页
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