A Gradient pH-Sensitive Polymer-Based Antiviral Strategy via Viroporin-Induced Membrane Acidification.

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作者： Yizhe,Sun ^[1] ; Lidong,Gong ^[1] ; Yue,Yin ^[1] ; Lei,Zhang ^[1] ; Qiangming,Sun ^[2] ; Kai,Feng ^[2] ; Yimin,Cui ^[3] ; Qiang,Zhang ^[3] ; Xuehui,Zhang ^[4] ; Xuliang,Deng ^[4] ; Fuping,You ^[1] ; Dan,Lu ^[1] ; Zhiqiang,Lin ^[1]

作者单位： Institute of Systems Biomedicine, Department of Pathology, Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, P. R. China. ^[1] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, 65018, P. R. China. ^[2] Department of Pharmacy Administration and Clinical Pharmacy, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. ^[3] National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China. ^[4]

关键词 coronavirus pH-sensitivity polymers viral envelopes viroporins

主题词动物(Animals);抗病毒药(Antiviral Agents);氢离子浓度(Hydrogen-Ion Concentration);小鼠(Mice);聚合物(Polymers);病毒(Viruses)

DOI 10.1002/adma.202109580

PMID 35229371

发布时间 2022-05-09

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准确一般字义偏差语意偏离译文作用小提交