Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.

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第一作者： Jiale,Ren

第一单位： CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University School of Medicine (SJTUSM) and Chinese Academy of Sciences, Shanghai, China.

作者： Jiale,Ren ^[1] ; Ni,Li ^[1] ; Siyu,Pei ^[1] ; Yannan,Lian ^[1] ; Li,Li ^[2] ; Yuchong,Peng ^[3] ; Qiuli,Liu ^[4] ; Jiacheng,Guo ^[1] ; Xuege,Wang ^[1] ; Ying,Han ^[1] ; Guoying,Zhang ^[1] ; Hanling,Wang ^[1] ; Yaqi,Li ^[5] ; Jun,Jiang ^[4] ; Qintong,Li ^[6] ; Minjia,Tan ^[7] ; Junjie,Peng ^[5] ; Guohong,Hu ^[1] ; Yichuan,Xiao ^[1] ; Xiong,Li ^[3] ; Moubin,Lin ^[2] ; Jun,Qin ^[1]

作者单位： CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University School of Medicine (SJTUSM) and Chinese Academy of Sciences, Shanghai, China. ^[1] Department of General Surgery, Department of Gastroenterology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China. ^[2] Center for Clinical Precision Pharmacy, The First Affiliated Hospital, School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China. ^[3] Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China. ^[4] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. ^[5] Department of Obstetrics, Gynecology and Pediatrics, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China. ^[6] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ^[7]

关键词 Antigen presentation Colorectal cancer Epigenetics Oncology