Sensitive LC-MS/MS quantification of unconjugated maytansinoid DM4 and its metabolite S-methyl-DM4 in human plasma.

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第一作者： Yunlin,Fu

第一单位： Pharmacokinetic Sciences - Drug Disposition, Novartis Institutes for BioMedical Research, One Health Plaza, East Hanover, NJ 07936, USA.

作者： Yunlin,Fu ^[1] ; Shashank,Gorityala ^[2] ; Wenkui,Li ^[1] ; David,Humphries ^[2] ; Aaron,Ledvina ^[2] ; Stephanie,Cape ^[2] ; Franck,Picard ^[3]

作者单位： Pharmacokinetic Sciences - Drug Disposition, Novartis Institutes for BioMedical Research, One Health Plaza, East Hanover, NJ 07936, USA. ^[1] Labcorp Drug Development, 3301 Kinsman Boulevard, Madison, WI 53704, USA. ^[2] Pharmacokinetic Sciences - Drug Disposition, Novartis Institutes for BioMedical Research, CH-4056, Basel, Switzerland. ^[3]

关键词 LC-MS/MS S-methyl-DM4 antibody–maytansinoid conjugate bioanalysis maytansinoid DM4 protein precipitation reduction

主题词色谱法, 液相(Chromatography, Liquid);人类(Humans);免疫轭合物(Immunoconjugates);美坦辛(Maytansine);串联质谱法(Tandem Mass Spectrometry)

DOI 10.4155/bio-2021-0275

PMID 35234045

发布时间 2022-03-28

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