首页> Cell reports> Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies.

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第一作者： Anusmita,Sahoo

第一单位： Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.

作者： Anusmita,Sahoo ^[1] ; Edgar A,Hodge ^[2] ; Celia C,LaBranche ^[3] ; Tiffany M,Styles ^[1] ; Xiaoying,Shen ^[3] ; Narayanaiah,Cheedarla ^[1] ; Ayalnesh,Shiferaw ^[1] ; Gabriel,Ozorowski ^[4] ; Wen-Hsin,Lee ^[4] ; Andrew B,Ward ^[4] ; Georgia D,Tomaras ^[3] ; David C,Montefiori ^[3] ; Darrell J,Irvine ^[5] ; Kelly K,Lee ^[2] ; Rama Rao,Amara ^[6]

作者单位： Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. ^[1] Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA. ^[2] Department of Surgery, Duke University Medical School, Duke University, Durham, NC 27710, USA. ^[3] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA 92121, USA. ^[4] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[5] Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: ramara@emory.edu. ^[6]

关键词 173 position C.1086 trimer HIV-1 vaccine V1V2 apex V1V2-scaffold specific V2 hotspot antigenic profile breadth immunogen neutralization time-dependent BLI