Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.

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第一作者： Brian A,Willis

第一单位： Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.

作者： Brian A,Willis ^[1] ; Stephen L,Lowe ^[2] ; Scott A,Monk ^[1] ; Patrick J,Cocke ^[1] ; Christopher D,Aluise ^[1] ; Leonard N,Boggs ^[1] ; Anthony R,Borders ^[1] ; Richard A,Brier ^[1] ; Robert A,Dean ^[1] ; Steven J,Green ^[1] ; Douglas E,James ^[1] ; Stanford S,Jhee ^[3] ; Qun,Lin ^[1] ; Albert C,Lo ^[1] ; Patrick C,May ^[1] ; Brian M,Watson ^[1] ; Leonard L,Winneroski ^[1] ; Zhixiang,Yang ^[1] ; Jennifer A,Zimmer ^[1] ; David L,McKinzie ^[1] ; Dustin J,Mergott ^[1]

作者单位： Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. ^[1] Lilly Centre for Clinical Pharmacology, Singapore, Singapore. ^[2] PAREXEL International, Glendale, CA, USA. ^[3]

关键词 Amyloid-β BACE1 inhibitor pharmacodynamics pharmacokinetics translational studies

DOI 10.3233/ADR-210037

PMID 35243208

发布时间 2022-05-02

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Journal of Alzheimer's disease reports

2022年6卷1期

1-15页

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Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.

Journal of Alzheimer's disease reports

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Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.

Journal of Alzheimer's disease reports

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Journal of Alzheimer's disease reports

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