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Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment.

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作者: Mi,Zhang [1] ; Wenhui,Hu [1] ; Chenhui,Cai [2] ; Yu,Wu [1] ; Jianmei,Li [3] ; Shiwu,Dong [1]
作者单位: Department of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing, 400038, China. [1] Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China. [2] School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. [3] State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, 400038, China. [4]
关键词 ACLT, anterior cruciate ligament transectionADAMTS, a disintegrin and metalloproteinase with thrombospondin motifsAIA, adjuvant-induced arthritisAMF, alternating magnetic fieldAPCs, antigen-presenting cellsBBR, berberineCAT, catalaseCD44, cluster of differentiation 44CEL, tripterineCEL-PRNPs, RGD-modified PLGA enzyme-responsive nanoparticles loaded with tripterineCIA, collagen-induced arthritisCTSK, cathepsin KCaP, calcium phosphateCartilage degenerationDCF, diclofenacDEX-P, dexamethasone sodium phosphateDMARDs, disease-modifying anti-rheumatic drugsDMM, destabilization of medial meniscusDex/Oxi-α CDNPs, 4-phenylborate-cyclodextrin biomaterial loaded with dexamethasoneECM, extracellular matrixELP, elastin-like peptideERK1/2, extracellular signal-regulated kinase 1/2FLSS, fibroblast synovial cellsGPX, glutathione peroxidaseGSH, glutathioneHA, hyaluronic acidHIFU, high intensity focused ultrasoundHM, hollow microsphereIBU, ibuprofenIGF-1, insulin-like growth factor-1IL, interleukinIL-1Ra, interleukin-1 receptor antagonistInflammatory arthritisK/BxN, the T cell receptor transgene KRN and the MHC class II moleculeKAFAK, KAFAKLAARLYRKALARQLGVAAKGN, kartogeninLDH, lactate dehydrogenaseLPS, lipopolysaccharideMAPK, mitogen-activated protein kinaseMFGCN, methotrexate-loaded folate-conjugated glycol chitosan nanoparticlesMHC, major histocompatibility complexMMPs, matrix metalloproteinasesMNPs, multifunctional nanoparticlesMOF, metal-organic frameworkMP-HANPs, mineralized nanoparticlesMPEG-PPF, methoxy polyethylene glycol-polypropylene fumarateMRI, magnetic resonance imagingMTX, methotrexateNADPH, nicotinamide adenine dinucleotide phosphateNFATc1, nuclear factor of activated T cell cytoplasmic 1NGPEGSS, nanoparticles with degradable disulfide crosslinksNIR, near-infraredNO, nitric oxideNP, nanoparticleNP-gel, nanoparticle-hydrogel hybrid systemNSAIDs, non-steroidal anti-inflammatory drugsNrf2, nuclear factor erythroid 2-related factor 2OA, osteoarthritisP-HA, polyethylene glycol hyaluronic acidPAMAM, poly (Ninylisobutyramide)PCA, protocatechuic acidPDEPT, pre-enzyme drug therapyPDT, photodynamic therapyPEG-PLGA-Au, polyethylene-glycol polylactic-glycolic acid gold-containing nanoparticlesPEOx-PPOy-PEOz, poly (ethylene oxide)-block-poly (Oxypropylene)-block-poly (ethylene oxide)PEVS, platelet-derived extracellular vesiclesPICsomes, polyion complex vesiclesPLCG1, phospholipase C gamma 1PLGA, polylactic-glycolic acidPMEOMA, poly [2-(2-methoxyethoxy) ethylmethacrylate]PNC, bisphosphonate-modified nanocellulosePNIPAM, poly (N-isopropyl acrylamide)PON1, paraoxonase-1POxs, poly (2-oxazoline)PPS, polyphenylene sulfidePTH, parathyroid hormonePTT, photothermal therapyQ, a tripeptide sequence QAWRA, rheumatoid arthritisRANKL, nuclear factor-kappa B ligandRFA, radiofrequency thermal ablationRGD, arginine-glycine-aspartic acidRMTQ, RGD-MMP-TAT-QAW peptideROS, reactive oxygen speciesRedox, reduction-oxidationSBC, sodium bicarbonateSOD, superoxide dismutaseSPION, superparamagnetic iron oxide nanoparticlesStimuli-responsive drug delivery systemSubchondral bone destructionSynovitisT cell, thymus cellT, cell-penetrating peptideTA, triamcinolone acetonideTAT, transcription-transactivatingTATQ, TAT-QAWTG-18, triglycerol monostearateTIMP, tissue inhibitor of metalloproteinaseTNF, tumor necrosis factorTR1, type 1 regulatoryTolDex, tolerogenic dendritic cell-derived exosomesUS, ultrasoundVEGF, vascular endothelial growth factorfMRI, focusing magnetic resonance imagingβ-TCP, β-tricalcium phosphate
DOI 10.1016/j.mtbio.2022.100223
PMID 35243298
发布时间 2022-03-05
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Materials today. Bio

2022年14卷

100223页

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