Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors.

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第一作者： Pei,Chen

第一单位： Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China.

作者： Pei,Chen ^[1] ; Huachao,Bin ^[2] ; Yan,Jiao ^[2] ; Guifeng,Lin ^[2] ; Yun,Zhang ^[3] ; Anjie,Xia ^[2] ; Zhilin,Pan ^[2] ; Jingxin,Qiao ^[2] ; Yinping,Guo ^[2] ; Jingming,Liu ^[2] ; Yangli,Zhou ^[2] ; Linli,Li ^[4]

作者单位： Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China. ^[1] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. ^[2] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Sichuan 610041, China. ^[3] Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan 610041, China. Electronic address: lilinli@scu.edu.cn. ^[4]

关键词 ATR kinase Ovarian cancer Small molecule inhibitor Structure–activity relationship

主题词 DNA损伤(DNA Damage);人类(Humans);肿瘤(Neoplasms);磷酰化(Phosphorylation);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘧啶类(Pyrimidines)

DOI 10.1016/j.bmcl.2022.128651

PMID 35245663

发布时间 2022-05-02

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