Enhancement of CD70-specific CAR T treatment by IFN-γ released from oHSV-1-infected glioblastoma.

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作者： Guidong,Zhu ^[1] ; Junwen,Zhang ^[2] ; Qing,Zhang ^[3] ; Guishan,Jin ^[4] ; Xiaodong,Su ^[1] ; Sisi,Liu ^[2] ; Fusheng,Liu ^[3]

作者单位： Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China. ^[1] Department of Neurosurgery, Beijing Tiantan Hospital Affiliated To Capital Medical University, Beijing, 100070, China. ^[2] Beijing Laboratory of Biomedical Materials, Beijing, 100070, China. ^[3] Shandong Second Provincial General Hospital, Shandong Provincial ENT Hospital, Jinan, 250031, China. ^[4] Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ^[5] Brain Tumor Research Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China. liufusheng@ccmu.edu.cn. ^[6] Department of Neurosurgery, Beijing Tiantan Hospital Affiliated To Capital Medical University, Beijing, 100070, China. liufusheng@ccmu.edu.cn. ^[7] Beijing Laboratory of Biomedical Materials, Beijing, 100070, China. liufusheng@ccmu.edu.cn. ^[8]

关键词 CD70 Chimeric antigen receptor Glioblastoma Immunotherapy Oncolytic herpes simplex virus-1 Tumor microenvironment