换一批
换一批Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease.
第一作者：
Steven N,Austad
第一单位：
Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
作者：
关键词
ACE2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2AD, Alzheimer's diseaseADP, adenosine diphosphateADRD, AD-related dementiasAβ, amyloid βCSF, cerebrospinal fluidCircadian regulationDAMPsDAMPs, damage-associated molecular patternsDiabetesER, estrogen receptorETC, electron transport chainFCCP, trifluoromethoxy carbonylcyanide phenylhydrazoneFPR-1, formyl peptide receptor 1GIP, glucose-dependent insulinotropic polypeptideGLP-1, glucagon-like peptide-1HBP, hexoamine biosynthesis pathwayHTRA, high temperature requirement AHexokinase biosynthesis pathwayI3A, indole-3-carboxaldehydeIRF-3, interferon regulatory factor 3LC3, microtubule associated protein light chain 3LPS, lipopolysaccharideLRR, leucine-rich repeatMAVS, mitochondrial anti-viral signalingMCI, mild cognitive impairmentMRI, magnetic resonance imagingMRS, magnetic resonance spectroscopyMdivi-1, mitochondrial division inhibitor 1MicrobiomeMitochondrial DNAMitochondrial electron transport chainMitochondrial quality controlNLRP3, leucine-rich repeat (LRR)-containing protein (NLR)-like receptor family pyrin domain containing 3NOD, nucleotide-binding oligomerization domainNeuN, neuronal nuclear proteinPET, fluorodeoxyglucose (FDG)-positron emission tomographyPKA, protein kinase APOLβ, the base-excision repair enzyme DNA polymerase βROS, reactive oxygen speciesReactive speciesSAMP8, senescence-accelerated miceSCFAs, short-chain fatty acidsSIRT3, NAD-dependent deacetylase sirtuin-3STING, stimulator of interferon genesSTZ, streptozotocinSkQ1, plastoquinonyldecyltriphenylphosphoniumT2D, type 2 diabetesTCA, Tricarboxylic acidTLR9, toll-like receptor 9TMAO, trimethylamine N-oxideTP, tricyclic pyroneTRF, time-restricted feedingcAMP, cyclic adenosine monophosphatecGAS, cyclic GMP/AMP synthasehAPP, human amyloid precursor proteinhPREP, human presequence proteasei.p., intraperitonealmTOR, mechanistic target of rapamycinmtDNA, mitochondrial DNAαkG, alpha-ketoglutarate
DOI
10.1016/j.apsb.2021.06.014
PMID
35256932
发布时间
2024-08-24
- 浏览7
Acta pharmaceutica Sinica. B
2022年12卷2期
511-531页
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