换一批Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice.
第一作者：
Mallory,Little
第一单位：
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
作者：
关键词
BA, bile acidBSH, bile salt hydrolaseBile acidsCA, cholic acidCARCAR, constitutive androstane receptorCDCA, chenodeoxycholic acidCITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oximeCV, conventionalCYP, cytochrome P450DCA, deoxycholic acidEGF, epidermal growth factorFecesGF, germ freeGLP-1, glucagon-like peptide-1GM-CSF, granulocyte-macrophage colony-stimulating factorGut microbiomeHDCA, hyodeoxycholic acidIBD, inflammatory bowel diseaseIFNγ, interferon-gammaIL, interleukinIS, internal standardsInflammationLCA, lithocholic acidLC–MS/MS, liquid chromatography–tandem mass spectrometryMCA, muricholic acidMCP-1, monocyte chemoattractant protein-1MiceNF-κB, nuclear factor kappa-light-chain-enhancer of activated B cellsNSAID, non-steroidal anti-inflammatory drugNuclear receptorOH, hydroxylatedOTUs, operational taxonomy unitsPA, indole-3 propionic acidPBDEs, polybrominated diphenyl ethersPCBs, polychlorinated biphenylsPCoA, Principle Coordinate AnalysisPXRPXR, pregnane X receptorPiCRUSt, Phylogenetic Investigation of Communities by Reconstruction of Observed StatesQIIME, Quantitative Insights Into Microbial EcologySCFAs, short-chain fatty acidsSNP, single-nucleotide polymorphismSPF, specific-pathogen-freeT, wild typeT-, taurine conjugatedTCPOBOP, 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3′,5,5′-Tetrachloro-1,4-bis(pyridyloxy)benzeneTGR-5, Takeda G-protein-coupled receptor 5TLR4, toll-like receptor 4TNF, tumor necrosis factorUDCA, ursodeoxycholic acidYAP, yes-associated proteinhPXR-TG, humanized PXR transgenic
DOI
10.1016/j.apsb.2021.07.022
PMID
35256948
发布时间
2024-05-12
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Acta pharmaceutica Sinica. B
2022年12卷2期
801-820页
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