Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID.

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作者： Kanchan,Bhatia ^[1] ; Adam,Kindelin ^[2] ; Muhammad,Nadeem ^[1] ; Mohammad Badruzzaman,Khan ^[3] ; Junxiang,Yin ^[4] ; Alberto,Fuentes ^[3] ; Karis,Miller ^[5] ; Gregory H,Turner ^[6] ; Mark C,Preul ^[1] ; Abdullah S,Ahmad ^[3] ; Elliott J,Mufson ^[6] ; Michael F,Waters ^[1] ; Saif,Ahmad ^[3] ; Andrew F,Ducruet ^[5]

作者单位： Department of Neurosurgery, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. ^[1] School of Mathematical and Natural Sciences, Arizona State University, Phoenix, AZ, USA. ^[2] Department of Translational Neuroscience, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. ^[3] Department of Neurology, Augusta University, Augusta, GA, 30912, USA. ^[4] Department of Neurology, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. ^[5] Barrow Neurological Institute/Arizona State University Center for Preclinical Imaging, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. ^[6] Department of Neurosurgery, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. saif.ahmad@barrowneuro.org. ^[7] Department of Translational Neuroscience, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85013, USA. saif.ahmad@barrowneuro.org. ^[8] Departments of Neurosurgery & Translational Neuroscience, Barrow Neurological Institute, SJHMC, Dignity Health, Phoenix, AZ, 85086, USA. andrew.ducruet@barrowbrainandspine.com. ^[9]

关键词 Cerebral blood flow (CBF), White matter degeneration (WMD)Complement C3a receptor (C3aR)Inflammation Vascular contributions to cognitive impairment and dementia (VCID)