Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures.

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第一作者： Ingrid,Jurickova

第一单位： Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA.

作者： Ingrid,Jurickova ^[1] ; Erin,Bonkowski ^[1] ; Elizabeth,Angerman ^[1] ; Elizabeth,Novak ^[2] ; Alex,Huron ^[1] ; Grayce,Akers ^[1] ; Kentaro,Iwasawa ^[1] ; Tzipi,Braun ^[3] ; Rotem,Hadar ^[4] ; Maria,Hooker ^[4] ; Sarah,Han ^[1] ; David J,Cutler ^[1] ; David T,Okou ^[5] ; Subra,Kugathasan ^[6] ; Anil,Jegga ^[6] ; James,Wells ^[3] ; Takanori,Takebe ^[7] ; Kevin P,Mollen ^[1] ; Yael,Haberman ^[7] ; Lee A,Denson ^[8]

作者单位： Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, the University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[1] Division of General and Thoracic Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ^[2] Division of Biomedical Informatics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[3] Department of Pediatrics, Sheba Medical Center, Tel-Aviv University, Tel-HaShomer, Israel. ^[4] Department of Human Genetics, Emory University, Atlanta, GA, USA. ^[5] Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA, USA. ^[6] Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[7] Institute of Research, Tokyo Medical and Dental University, Japan. ^[8]

关键词 NADPH oxidase fibrosis reactive oxygen species small molecule