Genomic analysis of paired IDHwt glioblastomas reveals recurrent alterations of MPDZ at relapse after radiotherapy and chemotherapy.

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第一作者： Brice,Chanez

第一单位： Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; APHM, CHU Timone, Service de Neurooncologie, Marseille, France.

作者： Brice,Chanez ^[1] ; Romain,Appay ^[2] ; Arnaud,Guille ^[3] ; Arnaud,Lagarde ^[4] ; Carole,Colin ^[5] ; José,Adelaide ^[3] ; Emilie,Denicolai ^[6] ; Carine,Jiguet-Jiglaire ^[5] ; Céline,Bequet ^[7] ; Thomas,Graillon ^[8] ; Sébastien,Boissonneau ^[8] ; Isabelle,Nanni-Metellus ^[9] ; Henry,Dufour ^[8] ; Dominique,Figarella-Branger ^[2] ; Olivier,Chinot ^[1] ; Emeline,Tabouret ^[10]

作者单位： Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; APHM, CHU Timone, Service de Neurooncologie, Marseille, France. ^[1] Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; APHM, Timone Hospital, Department of Anatomopathology, 13005 Marseille, France. ^[2] Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, Institut Paoli-Calmettes, Predictive Oncology Team, France. ^[3] APHM, Hôpital de la Conception, Service de Biologie Moléculaire, 13005 Marseille, France. ^[4] Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France. ^[5] Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, Institut Paoli-Calmettes, Predictive Oncology Team, France. ^[6] APHM, CHU Timone, Service de Neurooncologie, Marseille, France. ^[7] APHM, Timone Hospital, Department of Neuro-Surgery, 13005 Marseille, France. ^[8] APHM, North Hospital, Transfert Laboratory, 13015 Marseille, France. ^[9] Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; APHM, CHU Timone, Service de Neurooncologie, Marseille, France. Electronic address: emeline.tabouret@gmail.com. ^[10]

关键词 Comparative genomic hybridization array Glioblastoma MPDZ Next generation sequencing Paired Relapse