Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

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作者： Barthelemy,Caron ^[1] ; Etienne,Patin ^[2] ; Maxime,Rotival ^[2] ; Bruno,Charbit ^[3] ; Matthew L,Albert ^[4] ; Lluis,Quintana-Murci ^[5] ; Darragh,Duffy ^[6] ; Antonio,Rausell ^[7] ; Milieu Intérieur Consortium

作者单位： Université de Paris, INSERM UMR1163, Imagine Institute, Clinical Bioinformatics Laboratory, F-75006, Paris, France. ^[1] Human Evolutionary Genetics Unit, Institut Pasteur, UMR2000, CNRS, Université de Paris, F-75015, Paris, France. ^[2] Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Université de Paris, F-75015, Paris, France. ^[3] HIBIO, South San Francisco, CA, 94080, USA. ^[4] Human Evolutionary Genetics Unit, Institut Pasteur, UMR2000, CNRS, Université de Paris, F-75015, Paris, France.;Human Genomics and Evolution, Collège de France, F-75005, Paris, France. ^[5] Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Université de Paris, F-75015, Paris, France. darragh.duffy@pasteur.fr.;Translational Immunology Unit, Institut Pasteur, Université de Paris, F-75015, Paris, France. darragh.duffy@pasteur.fr. ^[6] Université de Paris, INSERM UMR1163, Imagine Institute, Clinical Bioinformatics Laboratory, F-75006, Paris, France. antonio.rausell@institutimagine.org.;Service de Médecine Génomique des Maladies Rares, AP-HP, Necker Hospital for Sick Children, F-75015, Paris, France. antonio.rausell@institutimagine.org. ^[7]

关键词 Immune cells Immune variability Plasma proteins pQTL

主题词血蛋白质类(Blood Proteins);全基因组关联研究(Genome-Wide Association Study);健康状况(Health Status);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci)

DOI 10.1186/s13073-022-01032-y

PMID 35264221

发布时间 2024-08-24

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