Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms.

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第一作者： Changqing,Xu

第一单位： Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

作者： Changqing,Xu ^[1] ; Barkha J,Yadav-Samudrala ^[1] ; Callie,Xu ^[1] ; Bhupendra,Nath ^[2] ; Twisha,Mistry ^[2] ; Wei,Jiang ^[3] ; Micah J,Niphakis ^[4] ; Benjamin F,Cravatt ^[4] ; Somnath,Mukhopadhyay ^[2] ; Aron H,Lichtman ^[5] ; Bogna M,Ignatowska-Jankowska ^[6] ; Sylvia,Fitting ^[1]

作者单位： Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[1] Department of Chemistry & Biochemistry, North Carolina Central University, Durham, NC 27707, USA. ^[2] Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.;Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. ^[3] Department of Chemical Physiology, Scripps Research Institute, La Jolla, CA 92037, USA. ^[4] Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA. ^[5] Neuronal Rhythms in Movement Unit, Okinawa Institute of Science and Technology, Onna 904-0495, Japan. ^[6]

关键词 PF3845 Tat transgenic mice anandamide cannabinoid type 1 receptor endocannabinoid enzyme inhibitor endocannabinoids fatty acid amide hydrolase inhibitory postsynaptic potentials neuroHIV non-eCB lipids

主题词酰胺基水解酶类(Amidohydrolases);动物(Animals);大麻酚类(Cannabinoids);内源性大麻酚类(Endocannabinoids);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);HIV感染(HIV Infections);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);哌啶类(Piperidines);吡啶类(Pyridines);受体, 大麻酚(Receptors, Cannabinoid);突触传递(Synaptic Transmission);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)

DOI 10.3390/cells11050857

PMID 35269478

发布时间 2024-06-01

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2022年11卷5期

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Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms.

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Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms.

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