Generation of a Dystrophin Mutant in Dog by Nuclear Transfer Using CRISPR/Cas9-Mediated Somatic Cells: A Preliminary Study.

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第一作者： Hyun Ju,Oh

第一单位： Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.

作者： Hyun Ju,Oh ^[1] ; Eugene,Chung ^[2] ; Jaehwan,Kim ^[3] ; Min Jung,Kim ^[4] ; Geon A,Kim ^[1] ; Seok Hee,Lee ^[1] ; Kihae,Ra ^[5] ; Kidong,Eom ^[1] ; Soojin,Park ^[1] ; Jong-Hee,Chae ^[4] ; Jin-Soo,Kim ^[6] ; Byeong Chun,Lee ^[6]

作者单位： Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea. ^[1] Center for Genome Engineering, Institute for Basic Science, Seoul 08826, Korea. ^[2] Department of Chemistry, Seoul National University, Seoul 08826, Korea. ^[3] Department of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul 5029, Korea. ^[4] Department of Clinical Pathology, College of Health Science, Eulji University, Uijeongbu 11759, Korea. ^[5] Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Korea. ^[6]

关键词 CRISPR/Cas9 dog dystrophin mutant somatic cell nuclear transfer

主题词动物(Animals);狗(Dogs);肌营养不良蛋白(Dystrophin);肌, 骨骼(Muscle, Skeletal);肌营养不良, 杜氏(Muscular Dystrophy, Duchenne);核移植技术(Nuclear Transfer Techniques)

DOI 10.3390/ijms23052898

PMID 35270040

发布时间 2022-04-08

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