首页> Journal of medicinal chemistry> Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.

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第一作者： Sandra,Codony

第一单位： Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain.

作者： Sandra,Codony ^[1] ; Caterina,Pont ^[1] ; Christian,Griñán-Ferré ^[2] ; Ania,Di Pede-Mattatelli ^[3] ; Carla,Calvó-Tusell ^[4] ; Ferran,Feixas ^[4] ; Sílvia,Osuna ^[5] ; Júlia,Jarné-Ferrer ^[2] ; Marina,Naldi ^[6] ; Manuela,Bartolini ^[6] ; María Isabel,Loza ^[7] ; José,Brea ^[7] ; Belén,Pérez ^[8] ; Clara,Bartra ^[9] ; Coral,Sanfeliu ^[9] ; Jordi,Juárez-Jiménez ^[3] ; Christophe,Morisseau ^[10] ; Bruce D,Hammock ^[10] ; Mercè,Pallàs ^[2] ; Santiago,Vázquez ^[1] ; Diego,Muñoz-Torrero ^[1]

作者单位： Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. ^[1] Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Neurosciences, University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. ^[2] Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028 Barcelona, Spain. ^[3] CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, E-17003 Girona, Spain. ^[4] CompBioLab Group, Departament de Química and Institut de Química Computacional i Catàlisi (IQCC), Universitat de Girona, C/ Maria Aurèlia Capmany 69, E-17003 Girona, Spain.;Institució Catalana de Recerca i Estudis Avançats (ICREA), E-08010 Barcelona, Spain. ^[5] Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, I-40126 Bologna, Italy. ^[6] BioFarma Research Group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Av. de Barcelona s/n, E-15782 Santiago de Compostela, Spain. ^[7] Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, E-08193 Bellaterra, Spain. ^[8] Institute of Biomedical Research of Barcelona, CSIC and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló, 149, E-08036 Barcelona, Spain. ^[9] Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, One Shields Avenue, Davis, California 95616, United States. ^[10]

医学主题词乙酰胆碱酯酶(Acetylcholinesterase);阿尔茨海默病(Alzheimer Disease);动物(Animals);胆碱酯酶抑制剂(Cholinesterase Inhibitors);疾病模型, 动物(Disease Models, Animal);环氧水解酶类(Epoxide Hydrolases);小鼠(Mice)

DOI 10.1021/acs.jmedchem.1c02150

PMID 35271276

发布时间 2023-02-15

基金项目

P42 ES004699/ES/NIEHS NIH HHS/United States R01 DK103616/DK/NIDDK NIH HHS/United States R01 DK107767/DK/NIDDK NIH HHS/United States R35 ES030443/ES/NIEHS NIH HHS/United States

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