Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor.

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作者： Christoph,Klenk ^[1] ; Leif,Hommers ^[2] ; Martin J,Lohse ^[3]

作者单位： Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany. ^[1] Interdisciplinary Center for Clinical Research, University Hospital of Würzburg, Würzburg, Germany.;Department of Psychiatry, Psychosomatics and Psychotherapy, Center for Mental Health, University Hospital of Würzburg, Würzburg, Germany.;Comprehensive Heart Failure Center (CHFC), University Hospital of Würzburg, Würzburg, Germany. ^[2] Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.;Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.;Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.;ISAR Bioscience Institute, Planegg, Germany. ^[3]

关键词 GPCRs biased signaling ectodomain cleavage matrix metalloproteinase parathyroid hormone 1 receptor

主题词配体(Ligands);甲状旁腺素(Parathyroid Hormone);受体, 甲状旁腺激素, 1型(Receptor, Parathyroid Hormone, Type 1);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)

DOI 10.3389/fendo.2022.839351

PMID 35273573

发布时间 2024-08-24

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