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CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome.

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第一作者： Sara,Pagnotta

第一单位： Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Laboratory affiliiated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

作者： Sara,Pagnotta ^[1] ; Antonella,Tramutola ^[1] ; Eugenio,Barone ^[1] ; Fabio,Di Domenico ^[1] ; Valeria,Pittalà ^[2] ; Loredana,Salerno ^[2] ; Valentina,Folgiero ^[3] ; Matteo,Caforio ^[3] ; Franco,Locatelli ^[4] ; Stefania,Petrini ^[5] ; D Allan,Butterfield ^[6] ; Marzia,Perluigi ^[7]

作者单位： Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Laboratory affiliiated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. ^[1] Department of Drug and Health Sciences, University of Catania, Catania, Italy. ^[2] Department of Pediatric Hematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Rome, Italy. ^[3] Department of Pediatric Hematology/Oncology and of Cell and Gene Therapy, Bambino Gesù Children's Hospital, Rome, Italy; Department of Pediatrics, Sapienza University of Rome, Rome, Italy. ^[4] Confocal Microscopy Core Facility, Ospedale Pediatrico Bambino Gesù, Rome, Italy. ^[5] Department of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. ^[6] Department of Biochemical Sciences "A. Rossi-Fanelli", Sapienza University of Rome, Laboratory affiliiated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. Electronic address: marzia.perluigi@uniroma1.it. ^[7]

关键词 BACH1 Down syndrome NRF2 Oxidative stress