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Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency.

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第一作者： Chao Zheng,Li

第一单位： Centre for Stem Cells and Regenerative Medicine, King's College London, London, UK.

作者： Chao Zheng,Li ^[1] ; Hiromi,Ogawa ^[2] ; Soon Seng,Ng ^[1] ; Xindi,Chen ^[2] ; Eriko,Kishimoto ^[2] ; Kokoro,Sakabe ^[2] ; Aiko,Fukami ^[2] ; Yueh-Chiang,Hu ^[2] ; Christopher N,Mayhew ^[2] ; Jennifer,Hellmann ^[3] ; Alexander,Miethke ^[3] ; Nahrin L,Tasnova ^[1] ; Samuel J I,Blackford ^[1] ; Zu Ming,Tang ^[4] ; Adam M,Syanda ^[1] ; Liang,Ma ^[1] ; Fang,Xiao ^[1] ; Melissa,Sambrotta ^[5] ; Oliver,Tavabie ^[5] ; Filipa,Soares ^[6] ; Oliver,Baker ^[7] ; Davide,Danovi ^[1] ; Hisamitsu,Hayashi ^[8] ; Richard J,Thompson ^[5] ; S Tamir,Rashid ^[1] ; Akihiro,Asai ^[3]

作者单位： Centre for Stem Cells and Regenerative Medicine, King's College London, London, UK. ^[1] Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[2] Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Department of Paediatrics, The University of Cincinnati, Cincinnati, OH, USA. ^[3] Stem Cell Hotel, King's College London, London, UK. ^[4] Institute of Liver Studies King's College London, London, United Kingdom. ^[5] Definigen, Cambridge, UK. ^[6] Genome Editing and Embryology Core Facility, King's College London, London, UK. ^[7] Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan. ^[8]

关键词 ALB, albumin ASGR2, asialoglycoprotein receptor 2 ATP1a1, ATPases subunit alpha-1 BMP4, bone morphogenetic protein 4 BSA-FAF, bovine serum albumin fatty acid-free BSEP, bile salt export pump Bile acid transport CDFDA, 5-(and-6)-carboxy-2′,7′-dichlorofluorescein Cellular polarity DE, definitive endoderm DILI, drug-induced liver injury FGF2, fibroblast growth factor 2 GCA, glycocholate GCDCA, glycochenodeoxycholate HCM, Hepatocyte Culture Medium HE, hepatic endodermal HGF, hepatocyte growth factor HNF4a, hepatic nuclear factor 4a MDCKII, Madin–Darby canine kidney II MRP2, multidrug resistance-associated protein 2 NTCP, Na+-TCA cotransporter PFIC (progressive familial intrahepatic cholestasis)PFIC, progressive familial intrahepatic cholestasis PI, propidium iodide RT-qPCR, quantitative reverse transcription PCR TCA, taurocholic acid TCDCA, taurochenodeoxycholate TEER, transepithelial electrical resistance TEM, transmission electron microscopy TJP1, tight junction protein 1 TJP2, tight junction protein 2 iHep, iPSC-derived hepatocytes iPSC, induced pluripotent stem cell sgRNA, single-guide RNA ssODN, single-stranded oligonucleotide-DNA

DOI 10.1016/j.jhepr.2022.100446

PMID 35284810

发布时间 2025-05-30

基金项目

MR/L006537/1/MRC_/Medical Research Council/United Kingdom P30 DK078392/DK/NIDDK NIH HHS/United States

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