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Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.

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第一作者: Eleonora,Khabirova
第一单位: Wellcome Sanger Institute, Hinxton, UK.
作者单位: Wellcome Sanger Institute, Hinxton, UK. [1] Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.;Haematology Department, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. [2] Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. [3] Wellcome Sanger Institute, Hinxton, UK.;Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.;Department of Paediatrics, University of Cambridge, Cambridge, UK. [4] Wellcome Sanger Institute, Hinxton, UK.;Department of Haematology, University College London Hospital, London, UK.;Department of Haematology, University College London Cancer Institute, London, UK. [5] Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK. [6] UCL Great Ormond Street Institute of Child Health, London, UK. [7] Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.;Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. [8] Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.;UCL Great Ormond Street Institute of Child Health, London, UK. [9] Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk.;The Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. s.n.bomken@newcastle.ac.uk. [10] Great Ormond Street Hospital for Children NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK. Jack.Bartram@gosh.nhs.uk.;UCL Great Ormond Street Institute of Child Health, London, UK. Jack.Bartram@gosh.nhs.uk. [11] Wellcome Sanger Institute, Hinxton, UK. m.a.haniffa@newcastle.ac.uk.;Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk.;Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. m.a.haniffa@newcastle.ac.uk. [12] Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.;Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.;Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk. [13]
DOI 10.1038/s41591-022-01720-7
PMID 35288693
发布时间 2025-05-30
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