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Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.

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作者单位: Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Medicine, Weill Cornell Medical College, New York, NY, USA.;Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA, USA. [1] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [2] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.;Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. [3] Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [4] Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. [5] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Weill Cornell Medical College, New York, NY, USA. [6] The Duchossois Family Institute, University of Chicago, Chicago, IL, USA. [7] Institute for Computational Medicine, New York University Langone Health, New York, NY, USA. [8] Molecular Microbiology Core Facility, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [9] Infectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY, USA. [10] Department of Medicine, Weill Cornell Medical College, New York, NY, USA.;Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [11] Department of Medicine, Weill Cornell Medical College, New York, NY, USA.;Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [12] Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Nursing, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [13] Division of Hematologic Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. [14] Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy. [15] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Department of Medicine, Weill Cornell Medical College, New York, NY, USA. [16] Department of Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. [17] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. [18] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.;Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. [19] The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [20] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.;Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.;Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. [21] Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [22] Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [23] Department of Medicine, Weill Cornell Medical College, New York, NY, USA.;Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [24] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, USA. [25] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. facciabe@pennmedicine.upenn.edu.;Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. facciabe@pennmedicine.upenn.edu.;Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA. facciabe@pennmedicine.upenn.edu. [26] Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. vandenbm@mskcc.org.;Department of Immunology, Sloan Kettering Institute, New York, NY, USA. vandenbm@mskcc.org. [27] Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.;Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu.;Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu. [28]
DOI 10.1038/s41591-022-01702-9
PMID 35288695
发布时间 2024-09-23
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