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Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation.

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第一作者： Ammar,Jabali

第一单位： Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.;Hector Institute for Translational Brain Research, Mannheim, Germany.;German Cancer Research Center, Heidelberg, Germany.;Institute of Reconstructive Neurobiology, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany.

作者： Ammar,Jabali ^[1] ; Anne,Hoffrichter ^[2] ; Ana,Uzquiano ^[3] ; Fabio,Marsoner ^[2] ; Ruven,Wilkens ^[2] ; Marco,Siekmann ^[2] ; Bettina,Bohl ^[2] ; Andrea C,Rossetti ^[2] ; Sandra,Horschitz ^[2] ; Philipp,Koch ^[2] ; Fiona,Francis ^[3] ; Julia,Ladewig ^[1]

作者单位： Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.;Hector Institute for Translational Brain Research, Mannheim, Germany.;German Cancer Research Center, Heidelberg, Germany.;Institute of Reconstructive Neurobiology, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany. ^[1] Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.;Hector Institute for Translational Brain Research, Mannheim, Germany.;German Cancer Research Center, Heidelberg, Germany. ^[2] INSERM U 1270, Paris, France.;Sorbonne Université, UMR-S 1270, Paris, France.;Institut du Fer à Moulin, Paris, France. ^[3]

关键词 EML1 YAP1 signaling cerebral organoids malformation of human cortical development perturbed progenitor cells

医学主题词大脑皮质(Cerebral Cortex);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);微管相关蛋白质类(Microtubule-Associated Proteins);突变(Mutation);神经元(Neurons);类器官(Organoids)

DOI 10.15252/embr.202154027

PMID 35289477

发布时间 2022-07-16

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