Transcriptional profiling demonstrates altered characteristics of CD8<sup>+</sup> cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia.

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作者： Milad,Abolhalaj ^[1] ; Viktor,Sincic ^[2] ; Henrik,Lilljebjörn ^[1] ; Carl,Sandén ^[2] ; Alar,Aab ^[3] ; Karin,Hägerbrand ^[3] ; Peter,Ellmark ^[1] ; Carl A K,Borrebaeck ^[2] ; Thoas,Fioretos ^[4] ; Kristina,Lundberg ^[1]

作者单位： Department of Immunotechnology, Medicon Village (Building 406), Lund University, Lund, Sweden. ^[1] CREATE Health Cancer Center, Medicon Village (Building 406), Lund University, Lund, Sweden. ^[2] Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. ^[3] Alligator Bioscience AB, Medicon Village, Lund, Sweden. ^[4] Department of Clinical Genetics and Pathology, University and Regional Laboratories Region Skåne, Lund, Sweden. ^[5]

关键词 TP53 RNA-sequencing T-cells acute myeloid leukemia immunotherapy

主题词 CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);突变(Mutation);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1002/cam4.4661

PMID 35297213

发布时间 2022-10-21

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Cancer medicine

2022年11卷15期

3023-3032页

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Transcriptional profiling demonstrates altered characteristics of CD8<sup>+</sup> cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia.

Cancer medicine

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Cancer medicine

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Transcriptional profiling demonstrates altered characteristics of CD8<sup>+</sup> cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia.

Cancer medicine

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Cancer medicine

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