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A general calculus of fitness landscapes finds genes under selection in cancers.

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作者单位: Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. [1] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. [2] Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas 77030, USA. [3] Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA. [4] Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030, USA. [5] Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA. [6] Departments of Statistics and Bioengineering, Rice University, Houston, Texas 77005, USA.;Department of Systems Engineering and Biology, Silesian University of Technology, 44-100 Gliwice, Poland. [7] Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA. [8] Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, USA. [9] Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.;Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.;Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas 77030, USA.;Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030, USA.;Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.;Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, Texas 77030, USA. [10]
DOI 10.1101/gr.275811.121
PMID 35301263
发布时间 2024-09-23
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