Immune phenotypic linkage between colorectal cancer and liver metastasis.

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作者： Yedan,Liu ^[1] ; Qiming,Zhang ^[1] ; Baocai,Xing ^[2] ; Nan,Luo ^[3] ; Ranran,Gao ^[1] ; Kezhuo,Yu ^[1] ; Xueda,Hu ^[1] ; Zhaode,Bu ^[4] ; Jirun,Peng ^[5] ; Xianwen,Ren ^[6] ; Zemin,Zhang ^[7]

作者单位： BIOPIC, School of Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. ^[1] Department of Hepatopancreatobiliary Surgery I, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China. ^[2] Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 10038, China. ^[3] Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China. ^[4] Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 10038, China; Ninth School of Clinical Medicine, Peking University, Beijing 10038, China. Electronic address: pengjr@bjsjth.cn. ^[5] BIOPIC, School of Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: renxwise@pku.edu.cn. ^[6] BIOPIC, School of Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, China. Electronic address: zemin@pku.edu.cn. ^[7]

关键词 CRC liver metastasis scRNA-seq tumor infiltrating tumor microenvironment

主题词 CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);结直肠肿瘤(Colorectal Neoplasms);人类(Humans);免疫疗法(Immunotherapy);肝肿瘤(Liver Neoplasms);肿瘤微环境(Tumor Microenvironment)

DOI 10.1016/j.ccell.2022.02.013

PMID 35303421

发布时间 2022-07-19

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