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BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma.

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第一作者： Yan-Ling,Chen

第一单位： Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, SIP, Suzhou, 215003, China.;School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, 215003, China.

作者： Yan-Ling,Chen ^[1] ; Xiao-Lu,Li ^[2] ; Gen,Li ^[2] ; Yan-Fang,Tao ^[2] ; Ran,Zhuo ^[2] ; Hai-Bo,Cao ^[2] ; Wan-Yan,Jiao ^[2] ; Zhi-Heng,Li ^[2] ; Zhen-Hong,Zhu ^[3] ; Fang,Fang ^[2] ; Yi,Xie ^[2] ; Xin-Mei,Liao ^[2] ; Di,Wu ^[2] ; Hai-Rong,Wang ^[2] ; Juan-Juan,Yu ^[2] ; Si-Qi,Jia ^[2] ; Yang,Yang ^[2] ; Chen-Xi,Feng ^[2] ; Peng-Cheng,Yang ^[2] ; Xiao-Dong,Fei ^[4] ; Jian-Wei,Wang ^[2] ; Yun-Yun,Xu ^[2] ; Guang-Hui,Qian ^[2] ; Zi-Mu,Zhang ^[5] ; Jian,Pan ^[6]

作者单位： Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, SIP, Suzhou, 215003, China.;School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, 215003, China. ^[1] Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, SIP, Suzhou, 215003, China. ^[2] Burn and Plastic Surgery, Children's Hospital of Soochow University, Suzhou, 215003, China. ^[3] Radiology Department, Children's Hospital of Soochow University, Suzhou, 215003, China. ^[4] Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, SIP, Suzhou, 215003, China. mumuhere@qq.com. ^[5] Institute of Pediatric Research, Children's Hospital of Soochow University, No. 92 Zhongnan Street, SIP, Suzhou, 215003, China. panjian2019@suda.edu.cn. ^[6]

关键词 BRD4 Broad H3K27ac domain Neuroblastoma PROTAC Super-enhancer

DOI 10.1186/s13578-022-00769-8

PMID 35303940

发布时间 2022-03-24

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