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p16<sup>INK4A</sup>-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.

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作者单位: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. [1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. [2] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. [3] Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. [4] College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China. [5] Department of Radiation Oncology, the first affiliated hospital of Sun Yat-Sen University, Guangzhou, 510080, P. R. China. [6] Key Laboratory of Bionic Engineering (Ministry of Education), College of Biological and Agricultural Engineering, Jilin University, Changchun, Jilin, 130022, P. R. China. [7] Department of Anesthesiology, Jilin Cancer Hospital, Changchun, Jilin, 130000, P. R. China. [8] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. [9] Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA. [10] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. jean_zhao@dfci.harvard.edu. [11] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. jean_zhao@dfci.harvard.edu. [12] Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA. jean_zhao@dfci.harvard.edu. [13]
DOI 10.1038/s41467-022-29081-2
PMID 35304445
发布时间 2023-03-17
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