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Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays.

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第一作者： Gina M,Hilton

第一单位： PETA Science Consortium International e.V., Stuttgart, Germany. Electronic address: GinaH@thepsci.eu.

作者： Gina M,Hilton ^[1] ; Catherine,Adcock ^[2] ; Gregory,Akerman ^[3] ; James,Baldassari ^[4] ; Michael,Battalora ^[4] ; Warren,Casey ^[5] ; Amy J,Clippinger ^[6] ; Rhian,Cope ^[7] ; Amber,Goetz ^[8] ; A Wallace,Hayes ^[9] ; Sabitha,Papineni ^[10] ; Richard C,Peffer ^[11] ; Deborah,Ramsingh ^[2] ; Brandy,Williamson Riffle ^[12] ; Mitscheli,Sanches da Rocha ^[12] ; Natalia,Ryan ^[8] ; Edward,Scollon ^[13] ; Nicolo,Visconti ^[14] ; Douglas C,Wolf ^[8] ; Zhongyu,Yan ^[15] ; Anna,Lowit ^[3]

作者单位： PETA Science Consortium International e.V., Stuttgart, Germany. Electronic address: GinaH@thepsci.eu. ^[1] Health Canada, Pest Management Regulatory Agency, Ottawa, Ontario, Canada. ^[2] United States Environmental Protection Agency, Office of Pesticide Programs, Washington DC, USA. ^[3] FMC Corporation, Newark, DE, USA. ^[4] Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ^[5] PETA Science Consortium International e.V., Stuttgart, Germany. ^[6] Australian Pesticides and Veterinary Medicines Authority, Armidale, New South Wales, Australia. ^[7] Syngenta Crop Protection, LLC, Greensboro, NC, USA. ^[8] University of South Florida College of Public Health, Tampa, FL, USA. ^[9] Labcorp Early Development Laboratories Inc, Greenfield, IN, USA. ^[10] Rich Peffer Toxicology Consulting, LLC, Greensboro, NC, USA. ^[11] BASF Corporation, Research Triangle Park, NC, USA. ^[12] Valent U.S.A. LLC, San Ramon, CA, USA. ^[13] Bayer CropScience LP, St. Louis, Missouri, USA. ^[14] Corteva Agriscience™, Indianapolis, IN, USA. ^[15]

关键词 Carcinogenicity Chronic toxicity Hazard classification Integrated approach to testing and assessment (IATA)Mode of action (MoA)New approach methodology (NAM)Reporting framework Risk assessment Rodent bioassay Weight of evidence (WoE)