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A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

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第一作者: Carlos,Sebastian
第一单位: Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.;Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultad de Biologia, Universitat de Barcelona (UB), 08028, Barcelona, Spain. csebastian@ub.edu.;Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain. csebastian@ub.edu.
作者单位: Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.;Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultad de Biologia, Universitat de Barcelona (UB), 08028, Barcelona, Spain. csebastian@ub.edu.;Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain. csebastian@ub.edu. [1] The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.;The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA. [2] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. [3] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA. [4] Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. [5] Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;University of Georgia, Athens, GA, USA. [6] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.;Department of Oncology, University of Torino, Turin, Italy. [7] Department of Oncology, University of Torino, Turin, Italy.;Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Experimentale et Clinique (IREC), UCLeuven, Brussels, Belgium. [8] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [9] Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.;Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [10] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.;Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [11] The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.;Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.;Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [12] Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.;Department of Medical Sciences, University of Torino, Turin, Italy. [13] Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.;Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.;Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA. [14] Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA. [15] The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.;The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.;The Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. rmostoslavsky@mgh.harvard.edu. [16]
DOI 10.1038/s41467-022-29085-y
PMID 35314684
发布时间 2023-07-01
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