Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines.

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作者： Alisa B,Nelson ^[1] ; Lisa S,Chow ^[2] ; Curtis C,Hughey ^[3] ; Peter A,Crawford ^[4] ; Patrycja,Puchalska ^[5]

作者单位： Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. ^[1] Division of Diabetes, Endocrinology and Metabolism; Department of Medicine, University of Minnesota, Minneapolis, MN, USA. ^[2] Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA. ^[3] Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA; Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. Electronic address: crawforp@umn.edu. ^[4] Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: ppuchals@umn.edu. ^[5]

关键词 LC-MS/MS adipose tissue insulin resistance isobaric FA dimers lipidomics lipids lipokines obesity olefinic bond spectral database

主题词色谱法, 液相(Chromatography, Liquid);酯类(Esters);脂肪酸类(Fatty Acids);人类(Humans);代谢组学(Metabolomics);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1016/j.jlr.2022.100201

PMID 35315332

发布时间 2024-09-23

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