Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.

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第一作者： Bohdan,Kysilov

第一单位： Institute of Physiology CAS, Prague 4, Czech Republic.

作者： Bohdan,Kysilov ^[1] ; Barbora,Hrcka Krausova ^[2] ; Vojtech,Vyklicky ^[1] ; Tereza,Smejkalova ^[1] ; Miloslav,Korinek ^[1] ; Martin,Horak ^[1] ; Hana,Chodounska ^[1] ; Eva,Kudova ^[3] ; Jiri,Cerny ^[3] ; Ladislav,Vyklicky ^[1]

作者单位： Institute of Physiology CAS, Prague 4, Czech Republic. ^[1] Third Faculty of Medicine, Charles University in Prague, Prague 10, Czech Republic. ^[2] Institute of Organic Chemistry and Biochemistry CAS, Prague 6, Czech Republic. ^[3]

关键词 GRIN channelopathy NMDA receptor positive allosteric modulator steroids transmembrane domain

主题词动物(Animals);突变(Mutation);孕烷类(Pregnanes);大鼠(Rats);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);甾类(Steroids)

DOI 10.1111/bph.15841

PMID 35318645

发布时间 2022-07-18

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