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High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis.

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第一作者： Andrew D,McCallum

第一单位： Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.;Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.;Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom.

作者： Andrew D,McCallum ^[1] ; Henry E,Pertinez ^[2] ; Aaron P,Chirambo ^[3] ; Irene,Sheha ^[3] ; Madalitso,Chasweka ^[3] ; Rose,Malamba ^[3] ; Doris,Shani ^[3] ; Alex,Chitani ^[4] ; Jane E,Mallewa ^[4] ; Jamilah Z,Meghji ^[5] ; Jehan F,Ghany ^[6] ; Elizabeth L,Corbett ^[7] ; Stephen B,Gordon ^[5] ; Geraint R,Davies ^[8] ; Saye H,Khoo ^[2] ; Derek J,Sloan ^[9] ; Henry C,Mwandumba ^[5]

作者单位： Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.;Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.;Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom. ^[1] Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom. ^[2] Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi. ^[3] Department of Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi. ^[4] Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.;Malawi-Liverpool-Wellcome Clinical Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi. ^[5] Department of Radiology, Royal Liverpool and Broadgreen University Hospitals, Liverpool, United Kingdom. ^[6] Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom. ^[7] Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom. ^[8] Infection and Global Health Division, University of St Andrews, St Andrews, United Kingdom. ^[9]

关键词 antibiotics antitubercular pharmacodynamics pharmacokinetics tuberculosis