Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist.

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第一作者： Ann M,Decker

第一单位： Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States.

作者： Ann M,Decker ^[1] ; Marcus F,Brackeen ^[1] ; Aida,Mohammadkhani ^[2] ; Chad M,Kormos ^[1] ; David,Hesk ^[1] ; Stephanie L,Borgland ^[2] ; Bruce E,Blough ^[1]

作者单位： Center for Drug Discovery, RTI International, Research Triangle Park, North Carolina 27709, United States. ^[1] Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N4N1, Canada. ^[2]

关键词 Parkinson’s disease cAMP functional assay dopaminergic neurons spontaneous firing rate structure?activity relationship trace amine-associated receptor 1 antagonist

主题词动物(Animals);人类(Humans);小鼠(Mice);大鼠(Rats);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);构效关系(Structure-Activity Relationship)

DOI 10.1021/acschemneuro.2c00086

PMID 35325532

发布时间 2022-12-09

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准确一般字义偏差语意偏离译文作用小提交