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Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.

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第一作者: Teodor,Dimitrov
第一单位: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076, Tübingen, Germany.
作者单位: Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076, Tübingen, Germany. [1] Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany. [2] Department of Internal Medicine VIII, University Hospital of Tübingen, 72076, Tübingen, Germany; German Cancer Research Consortium (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. [3] Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany; Department of Internal Medicine VIII, University Hospital of Tübingen, 72076, Tübingen, Germany; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211, Kuopio, Finland. [4] Department of Pharmaceutical (Bio-)Analysis, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany. [5] Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438, Frankfurt, Germany; Structure Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Goethe University Frankfurt, 60438, Frankfurt, Germany. [6] Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076, Tübingen, Germany; Department of Internal Medicine VIII, University Hospital of Tübingen, 72076, Tübingen, Germany; German Cancer Research Consortium (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. [7] Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076, Tübingen, Germany; German Cancer Research Consortium (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. Electronic address: michael.forster@uni-tuebingen.de. [8] Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität, 72076, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076, Tübingen, Germany; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076, Tübingen, Germany. Electronic address: stefan.laufer@uni-tuebingen.de. [9]
DOI 10.1016/j.ejmech.2022.114234
PMID 35325634
发布时间 2022-04-25
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European journal of medicinal chemistry

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