首页> Biomolecules> Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine.

Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine.

导出 LinkOut

翻译打印收藏纠错

第一作者： Yusuke,Mizobuchi

第一单位： Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama-shi 700-8558, Japan.;Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.;Department of Anesthesiology and Critical Care Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

作者： Yusuke,Mizobuchi ^[1] ; Kanako,Miyano ^[2] ; Sei,Manabe ^[3] ; Eiko,Uezono ^[4] ; Akane,Komatsu ^[5] ; Yui,Kuroda ^[5] ; Miki,Nonaka ^[2] ; Yoshikazu,Matsuoka ^[3] ; Tetsufumi,Sato ^[6] ; Yasuhito,Uezono ^[7] ; Hiroshi,Morimatsu ^[8]

作者单位： Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama-shi 700-8558, Japan.;Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.;Department of Anesthesiology and Critical Care Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ^[1] Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan. ^[2] Department of Anesthesiology and Resuscitology, Okayama University Hospital, 2-5-1 Shikatacho, Kita-ku, Okayama-shi 700-8558, Japan. ^[3] Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.;Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. ^[4] Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. ^[5] Department of Anesthesiology and Critical Care Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ^[6] Department of Pain Control Research, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.;Supportive and Palliative Care Research Support Office, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi 277-8577, Japan. ^[7] Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kita-ku, Okayama-shi 700-8558, Japan.;Department of Anesthesiology and Resuscitology, Okayama University Hospital, 2-5-1 Shikatacho, Kita-ku, Okayama-shi 700-8558, Japan. ^[8]

关键词 G protein receptor kinase desensitization fentanyl ketamine morphine tolerance μ-opioid receptor β-arrestin

医学主题词镇痛药, 阿片类(Analgesics, Opioid);药物耐受性(Drug Tolerance);芬太尼(Fentanyl);人类(Humans);氯胺酮(Ketamine);吗啡(Morphine);受体, 阿片样(Receptors, Opioid)

DOI 10.3390/biom12030426

PMID 35327617

发布时间 2024-08-25

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交