Identification of Genetic Risk Factors of Severe COVID-19 Using Extensive Phenotypic Data: A Proof-of-Concept Study in a Cohort of Russian Patients.

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第一作者： Sergey G,Shcherbak

第一单位： St. Petersburg State University, 199034 St. Petersburg, Russia.

作者： Sergey G,Shcherbak ^[1] ; Anton I,Changalidi ^[2] ; Yury A,Barbitoff ^[1] ; Anna Yu,Anisenkova ^[3] ; Sergei V,Mosenko ^[4] ; Zakhar P,Asaulenko ^[1] ; Victoria V,Tsay ^[3] ; Dmitrii E,Polev ^[5] ; Roman S,Kalinin ^[1] ; Yuri A,Eismont ^[2] ; Andrey S,Glotov ^[1] ; Evgeny Y,Garbuzov ^[2] ; Alexander N,Chernov ^[2] ; Olga A,Klitsenko ^[6] ; Mikhail O,Ushakov ^[2] ; Anton E,Shikov ^[7] ; Stanislav P,Urazov ^[2] ; Vladislav S,Baranov ^[5] ; Oleg S,Glotov ^[2]

作者单位： St. Petersburg State University, 199034 St. Petersburg, Russia. ^[1] City Hospital No. 40, 197706 St. Petersburg, Russia. ^[2] Bioinformatics Institute, 197342 St. Petersburg, Russia. ^[3] Faculty of Software Engineering and Computer Systems, ITMO University, 197101 St. Petersburg, Russia. ^[4] D.O. Ott Research Institute of Obstetrics, Gynaecology, and Reproductology, 199034 St. Petersburg, Russia. ^[5] North-Western State Medical University Named after Ivan Ivanovich (I.I.) Mechnikov, 195067 St. Petersburg, Russia. ^[6] Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency, 197022 St. Petersburg, Russia. ^[7] Institute of Experimental Medicine, 197376 St. Petersburg, Russia. ^[8] Laboratory for Proteomics of Supra-Organismal Systems, All-Russia Research Institute for Agricultural Microbiology (ARRIAM), 196608 St. Petersburg, Russia. ^[9]

关键词 COVID-19 GWAS NGS deep phenotyping genetic associations genetic variants severity

主题词队列研究(Cohort Studies);全基因组关联研究(Genome-Wide Association Study);人类(Humans);疾病大流行(Pandemics);危险因素(Risk Factors);俄罗斯(Russia)

DOI 10.3390/genes13030534

PMID 35328087

发布时间 2023-03-08

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