Blood Transcriptome Profiling Links Immunity to Disease Severity in Myotonic Dystrophy Type 1 (DM1).

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第一作者： Sylvia,Nieuwenhuis

第一单位： Center for Molecular and Biomolecular Informatics (CMBI), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.;Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, 6525 EN Nijmegen, The Netherlands.

作者： Sylvia,Nieuwenhuis ^[1] ; Joanna,Widomska ^[2] ; Paul,Blom ^[3] ; Peter-Bram A C,'t Hoen ^[4] ; Baziel G M,van Engelen ^[5] ; Jeffrey C,Glennon ^[6] ; On Behalf Of The Optimistic Consortium

作者单位： Center for Molecular and Biomolecular Informatics (CMBI), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.;Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, 6525 EN Nijmegen, The Netherlands. ^[1] Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, 6525 EN Nijmegen, The Netherlands. ^[2] VDL Enabling Technologies Group B.V., 5651 GH Eindhoven, The Netherlands. ^[3] Center for Molecular and Biomolecular Informatics (CMBI), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. ^[4] Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. ^[5] Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, 6525 EN Nijmegen, The Netherlands.;Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland. ^[6]

关键词 DM1 disease severity RNA sequencing blood immunity muscle impairment rating scale (MIRS)myotonic dystrophy type 1 (DM1)pathway analysis

主题词基因表达谱(Gene Expression Profiling);人类(Humans);营养不良性肌强直(Myotonic Dystrophy);生活质量(Quality of Life);疾病严重程度指数(Severity of Illness Index)

DOI 10.3390/ijms23063081

PMID 35328504

发布时间 2024-08-25

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